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Lead exposure-induced changes in hematology and biomarkers of hepatic injury: protective role of TrévoTM supplement
    Younsang Cho | 2022.05.09
Lead exposure has been linked to health challenges involving multiple organ failure. More than fifty percent of lead present in the human body is
accumulated in the liver causing hepatic injury. A major mechanism of lead toxicity is oxidative stress. TrvoTM is a nutritional supplement with
numerous bioactive natural products with detoxifying and antioxidant properties. This study was designed to investigate the hepatoprotective
of TrvoTM dietary supplements against lead-hepatotoxicity in male Wistar rats. Thirty-five healthy animals were divided into five groups of seven
each as follows: Group I=control; II=15 mg/kg of lead acetate (PbA); III= 2 mL/kg of TrvoTM + PbA; IV= 5 mL/kg of TrvoTM + PbA;V=5 mL/kg of
TrvoTM . Animals were orally treated with TrvoTM for two days before co-administration with PbA intraperitoneally for 12 consecutive days.
were sacrificed 24 h after the last administration and blood were collected via cardiac puncture and processed for hematological parameters and
assessment of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and albumin (ALB). The liver was excised and processed for markers
of oxidative stress and histopathological examination. Intraperitoneal administration of 15 mg/kg of PbA caused a significant increase in serum
concentration of AST, ALT, while the concentration of ALB was significantly decreased (P<0.001). PbA caused a significant reduction in packed cell
volume, hemoglobin while the total white blood cell count, neutrophils, lymphocytes, monocytes, eosinophils, and basophils were increased.
stress was significantly pronounced in the liver of rats exposed to PbA as observed in the high concentration of malonedialdehyde, decreased
concentration of glutathione, the activity of catalase, superoxide dismutase, and glutathione-S-transferase. Pretreatment with TrvoTM was able to
significantly prevent the anemic, oxidative damage, and hepatic injury initiated by PbA. Histological examination also corroborated the
results. In conclusion, the study reveals that TrvoTM is effective in attenuating PbA-induced hepatotoxicity in male Wistar rats.

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